Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains
نویسندگان
چکیده
Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers have been extensively utilized in optical stimulation devices optogenetics. However, the use of results small photo-stimulation region. In this study, micro-LED array were developed to achieve large-area brain large animal, such as macaque monkeys. Planar and linear designed fabricated photo-stimulate prefrontal cortex (PFC) ventral tegmental area (VTA) induce neurochemical response. Device operation, intensity, safety first characterized rats. Subsequently, used addition, microdialysis PFC was performed. The detected modulated levels dopamine brains. Thus, both VTA successfully achieved, effectiveness demonstrated. study will help facilitate further studies on system-wide optogenetic manipulation animals.
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ژورنال
عنوان ژورنال: IEEE Access
سال: 2021
ISSN: ['2169-3536']
DOI: https://doi.org/10.1109/access.2021.3111666